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Article

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016

Lacroix Matthieu, Rodier Geneviève, Kirsh Olivier, Houles Thibault, Delpech Hélène, Seyran Berfin, Gayte Laurie, Casas Francois, Pessemesse Laurence, Heuillet Maud, Bellvert Floriant, Portais Jean-Charles, Berthet Charlene, Bernex Florence, Brivet Michele, Boutron Audrey, Le Cam Laurent, Sardet Claude

Abstract excerpt

The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyruvate oxidation and fuels the tricarboxylic acid cycle to meet energy demand. Here, we reveal another level of regulation of the pyruvate oxidation pathway in mammals implicating the E4 transcription factor 1 (E4F1). E4F1 controls a set of four genes [dihydrolipoamide acetlytransferase (Dlat),...

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Identifiers

PMID: 27621446
DOI: 10.1073/pnas.1602754113
PMCID: PMC5047171

Genes

PDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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