Article

Pyruvate dehydrogenase kinase expression profile is a biomarker for cancer sensitivity to dichloroacetate-mediated growth inhibition

2023-09-22

Abstract excerpt

<h4>Background</h4> Cancer cells favour glycolysis and lactate production over mitochondrial metabolism despite the presence of oxygen (the Warburg effect). Increased pyruvate dehydrogenase kinase (PDK) activity contributes to this glycolytic phenotype. Dichloroacetate (DCA) is a PDK inhibitor with anti-cancer potential that inhibits all four isoforms of PDK but with differing potencies, thus expression of differ...

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Literature Corpus work: 286b1c65-bcfe-58b9-9044-c49eff5d6f1a
DOI: 10.1101/2023.09.18.557101

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