Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression.

Brain pathology (Zurich, Switzerland) - 1 Mar 2014

Goutagny Stéphane, Nault Jean C, Mallet Maxime, Henin Dominique, Rossi Jessica Z, Kalamarides Michel

Abstract excerpt

Meningiomas are common central nervous system tumors. The World Health Organization (WHO) defines three grades, predictive of the risk of recurrence. These tumors can relapse frequently and sometimes undergo malignant transformation. Maintenance of telomere length is a key process in malignant progression, and mutations in TERT promoter have recently been identified in various types of cancer. We sequenced the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Incidence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meningeal Neoplasms

Share to Meningioma

Share to Mutation

Share to Neoplasm Recurrence, Local

Share to Promoter Regions, Genetic

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 24261697
DOI: 10.1111/bpa.12110
PMCID: PMC8029399

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression.PMID 24261697Read ↗

TERT promoter mutations in primary and secondary WHO grade III meningiomaSemantic proximity Read ↗

TERT promoter mutation is associated with worse prognosis in WHO grade II and III meningiomas.Semantic proximity Read ↗

TERT Promoter Mutations and Risk of Recurrence in Meningioma.Semantic proximity Read ↗

Poor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis.Semantic proximity Read ↗

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma.Semantic proximity Read ↗

Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma.Semantic proximity Read ↗

TERT, a promoter of CNS malignanciesSemantic proximity Read ↗

ARID1A and TERT promoter mutations in dedifferentiated meningioma.Semantic proximity Read ↗

The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis.Semantic proximity Read ↗

Human TERT Promoter Mutations in Atypical and Anaplastic MeningiomasSemantic proximity Read ↗

Meningioma Grading beyond Histopathology: Relevance of Epigenetic and Genetic Features to Predict Clinical OutcomeSemantic proximity Read ↗

Progression-Free Survival and Molecular Features of Recurrent Intracranial Meningiomas: A Single-Center Retrospective StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.