TERT Promoter Mutations and Risk of Recurrence in Meningioma.

doi:10.1093/jnci/djv377

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Article

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

Journal of the National Cancer Institute - 1 May 2016

Sahm Felix, Schrimpf Daniel, Olar Adriana, Koelsche Christian, Reuss David, Bissel Juliane, Kratz Annekathrin, Capper David, Schefzyk Sebastian, Hielscher Thomas, Wang Qianghu, Sulman Erik P, Adeberg Sebastian, Koch Arend, Okuducu Ali Fuat, Brehmer Stefanie, Schittenhelm Jens, Becker Albert, Brokinkel Benjamin, Schmidt Melissa, Ull Theresa, Gousias Konstantinos, Kessler Almuth Friederike, Lamszus Katrin, Debus Jürgen, Mawrin Christian, Kim Yoo-Jin, Simon Matthias, Ketter Ralf, Paulus Werner, Aldape Kenneth D, Herold-Mende Christel, von Deimling Andreas

Abstract excerpt

The World Health Organization (WHO) classification and grading system attempts to predict the clinical course of meningiomas based on morphological parameters. However, because of high interobserver variation of some criteria, more reliable prognostic markers are required. Here, we assessed the TERT promoter for mutations in the hotspot regions C228T and C250T in meningioma samples from 252 patients. Mutations...

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PMID: 26668184
DOI: 10.1093/jnci/djv377
PMCID: PMC4849806

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TERT

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