Article
High incidence of TERT mutation in brain tumor cell lines.
Brain tumor pathology - 1 Jul 2016
Johanns Tanner M, Fu Yujie, Kobayashi Dale K, Mei Yu, Dunn Ian F, Mao Diane D, Kim Albert H, Dunn Gavin P
Abstract excerpt
TERT promoter gene mutations are highly recurrent in malignant glioma. However, little information exists regarding their presence in experimental brain tumor models. To better characterize systems in which TERT mutation studies could be appropriately modeled experimentally, the TERT promoter was examined by conventional sequencing in primary brain tumor initiating cells (BTIC), two matched recurrent BTIC lines,...
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