Article
Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma.
Neuropathology and applied neurobiology - 1 Apr 2022
Mirian Christian, Grell Kathrine, Juratli Tareq A, Sahm Felix, Spiegl-Kreinecker Sabine, Peyre Matthieu, Biczok Annamaria, Tonn Jörg-Christian, Goutagny Stéphane, Bertero Luca, Maier Andrea Daniela, Jensen Lasse Rehné, Schackert Gabriele, Broholm Helle, Scheie David, Cahill Daniel P, Brastianos Priscilla K, Skjøth-Rasmussen Jane, Fugleholm Kåre, Ziebell Morten, Munch Tina Nørgaard, Kristensen Bjarne Winther, Mathiesen Tiit
Abstract excerpt
TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the...
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