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RNA expression analysis of efflux pump genes in clinical isolates of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis in South Korea.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2017

Oh Tae Sang, Kim Young Jin, Kang Hee Yoon, Kim Chang-Ki, Cho Sun Young, Lee Hee Joo

Abstract excerpt

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is an important communicable disease. Various mechanisms of resistance to antituberculosis drugs have been reported; these are principally mutations in target genes. However, not all M. tuberculosis resistance can be explained by mutations in such genes. Other resistance mechanisms associated with drug transport, such as efflux pumps, have...

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PMID: 28062386
DOI: 10.1016/j.meegid.2017.01.002

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CPM

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