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Article

Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides.

BMC microbiology - 30 Oct 2025

Guo Yinjuan, Yang Jinghui, Wang Hongxiu, Sha Wei, Yu Fangyou

Abstract excerpt

The aminoglycosides are essential drugs in the treatment of multidrug-resistant tuberculosis. Antibiotic resistance of Mycobacterium tuberculosis is a major public health concern worldwide. Therefore, it is of great significance to characterize the mutations by which susceptible M. tuberculosis evolves into drug resistance. A total of 110 clinical isolates of MDR-TB were used for Whole-genome sequencing (WGS) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41168684
DOI: 10.1186/s12866-025-04446-x
PMCID: PMC12574157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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