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Article

eis Promoter C14G and C15G Mutations Do Not Confer Kanamycin Resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Dec 2016

Pholwat Suporn, Stroup Suzanne, Heysell Scott, Ogarkov Oleg, Zhdanova Svetlana, Ramakrishnan Girija, Houpt Eric

Abstract excerpt

We studied the significance of particular eis mutations on Mycobacterium tuberculosis drug resistance using a specialized transduction strategy. Recombinant strains harboring eis promoter mutations C14T, C12T, and G10A exhibited kanamycin resistance with MICs of 40, 10, and 20 μg/ml, respectively, while recombinant strains harboring C14G and C15G mutations were kanamycin susceptible (MIC, 2.5 to 5 μg/ml). Each of...

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Identifiers

PMID: 27736762
DOI: 10.1128/AAC.01775-16
PMCID: PMC5119041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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