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Article

UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

9 Jul 2018

Abstract excerpt

To explain the excess cancer rate in males, several candidates for "escape from X-inactivation tumor-suppressor" (EXITS) were recently identified. In this report we provide direct experimental evidence supporting UTX's role as an EXITS gene. Using a mouse lymphoma model, we show clear dosage effect of UTX copy number during tumorigenesis, which strongly supports the EXITS theory. Importantly, UTX deletion not...

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PMID: 30006524
DOI: 10.1038/s41467-018-05084-w

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