Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.

doi:10.1186/s13045-021-01032-2

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Article

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.

Journal of hematology & oncology - 15 Jan 2021

Walker Janek S, Hing Zachary A, Harrington Bonnie, Baumhardt Jordan, Ozer Hatice Gulcin, Lehman Amy, Giacopelli Brian, Beaver Larry, Williams Katie, Skinner Jordan N, Cempre Casey B, Sun Qingxiang, Shacham Sharon, Stromberg Benjamin R, Summers Matthew K, Abruzzo Lynne V, Rassenti Laura, Kipps Thomas J, Parikh Sameer, Kay Neil E, Rogers Kerry A, Woyach Jennifer A, Coppola Vincenzo, Chook Yuh Min, Oakes Christopher, Byrd John C, Lapalombella Rosa

Abstract excerpt

BACKGROUND: Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we found to disrupt highly conserved biophysical interactions in the NES-binding groove, conferring novel cargo-binding abilities and forcing cellular mis-localization of critical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Leukemic

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Identifiers

PMID: 33451349
DOI: 10.1186/s13045-021-01032-2
PMCID: PMC7809770

Genes

XPO1
NES

Variants

Provenance

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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.PMID 33451349Read ↗

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