Article
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.
Blood - 1 Jan 2015
Van der Meulen Joni, Sanghvi Viraj, Mavrakis Konstantinos, Durinck Kaat, Fang Fang, Matthijssens Filip, Rondou Pieter, Rosen Monica, Pieters Tim, Vandenberghe Peter, Delabesse Eric, Lammens Tim, De Moerloose Barbara, Menten Björn, Van Roy Nadine, Verhasselt Bruno, Poppe Bruce, Benoit Yves, Taghon Tom, Melnick Ari M, Speleman Frank, Wendel Hans-Guido, Van Vlierberghe Pieter
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that is mainly diagnosed in children and shows a skewed gender distribution toward males. In this study, we report somatic loss-of-function mutations in the X-linked histone H3K27me3 demethylase ubiquitously transcribed...
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