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Article

Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice.

Oncogene - 1 Apr 2024

Hendrickson Peter G, Oristian Kristianne M, Browne MaKenna R, Luo Lixia, Ma Yan, Cardona Diana M, Nash Joshua O, Ballester Pedro L, Davidson Scott, Shlien Adam, Linardic Corinne M, Kirsch David G

Abstract excerpt

CIC::DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and DUX4. Currently, there are no effective treatments and efforts to identify and translate better therapies are limited by the scarcity of patient tumor samples and cell lines. To address this limitation, we generated three genetically engineered mouse...

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Identifiers

PMID: 38413794
DOI: 10.1038/s41388-024-02984-8
PMCID: PMC11027086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice.PMID 38413794Read ↗

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