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Article

Inactivating CUX1 mutations promote tumorigenesis.

Nature genetics - 1 Jan 2014

Wong Chi C, Martincorena Inigo, Rust Alistair G, Rashid Mamunur, Alifrangis Constantine, Alexandrov Ludmil B, Tiffen Jessamy C, Kober Christina, Green Anthony R, Massie Charles E, Nangalia Jyoti, Lempidaki Stella, Döhner Hartmut, Döhner Konstanze, Bray Sarah J, McDermott Ultan, Papaemmanuil Elli, Campbell Peter J, Adams David J

Abstract excerpt

A major challenge in cancer genetics is to determine which low-frequency somatic mutations are drivers of tumorigenesis. Here we interrogate the genomes of 7,651 diverse human cancers and find inactivating mutations in the homeodomain transcription factor gene CUX1 (cut-like homeobox 1) in ~1-5%...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24316979
DOI: 10.1038/ng.2846
PMCID: PMC3874239

Genes

CUX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24316979-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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