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Article

Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design.

Virology - 1 Feb 2021

Ojwach Doty B A, Madlala Paradise, Gordon Michelle, Ndung'u Thumbi, Mann Jaclyn K

Abstract excerpt

Identification of viral immune escape mutations that compromise HIV's ability to replicate may aid rational attenuation-based vaccine design. Previously we reported amino acids associated with altered viral replication capacity (RC) from a sequence-function analysis of 487 patient-derived RT-integrase sequences. In this study, site-directed mutagenesis experiments were performed to validate the effect of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33316731
DOI: 10.1016/j.virol.2020.12.003
PMCID: PMC7931244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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