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Article

RNA-seq analysis identifies different transcriptomic types and developmental trajectories of primary melanomas.

Oncogene - 1 Nov 2018

Kunz Manfred, Löffler-Wirth Henry, Dannemann Michael, Willscher Edith, Doose Gero, Kelso Janet, Kottek Tina, Nickel Birgit, Hopp Lydia, Landsberg Jenny, Hoffmann Steve, Tüting Thomas, Zigrino Paola, Mauch Cornelia, Utikal Jochen, Ziemer Mirjana, Schulze Hans-Joachim, Hölzel Michael, Roesch Alexander, Kneitz Susanne, Meierjohann Svenja, Bosserhoff Anja, Binder Hans, Schartl Manfred

Abstract excerpt

Recent studies revealed trajectories of mutational events in early melanomagenesis, but the accompanying changes in gene expression are far less understood. Therefore, we performed a comprehensive RNA-seq analysis of laser-microdissected melanocytic nevi (n = 23) and primary melanoma samples (n = 57) and characterized the molecular mechanisms of early melanoma development. Using self-organizing maps, unsupervised...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microphthalmia-Associated Transcription Factor

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Identifiers

PMID: 29995873
DOI: 10.1038/s41388-018-0385-y

Genes

BRAF
NRAS
AXL
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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