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Article

Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.

Cancer cell - 9 Jul 2018

Shain A Hunter, Joseph Nancy M, Yu Richard, Benhamida Jamal, Liu Shanshan, Prow Tarl, Ruben Beth, North Jeffrey, Pincus Laura, Yeh Iwei, Judson Robert, Bastian Boris C

Abstract excerpt

We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically distinct areas of melanocytic neoplasia from 82 patients. Somatic alterations sequentially induced...

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Identifiers

PMID: 29990500
DOI: 10.1016/j.ccell.2018.06.005
PMCID: PMC6319271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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