Article
The gene expression signatures of melanoma progression.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2005
Haqq Christopher, Nosrati Mehdi, Sudilovsky Daniel, Crothers Julia, Khodabakhsh Daniel, Pulliam Brian L, Federman Scot, Miller James R, Allen Robert E, Singer Mark I, Leong Stanley P L, Ljung Britt-Marie, Sagebiel Richard W, Kashani-Sabet Mohammed
Abstract excerpt
Because of the paucity of available tissue, little information has previously been available regarding the gene expression profiles of primary melanomas. To understand the molecular basis of melanoma progression, we compared the gene expression profiles of a series of nevi, primary melanomas, and melanoma metastases. We found that metastatic melanomas exhibit two dichotomous patterns of gene expression, which...
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