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Article

Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?

Kidney international - 1 Sept 2008

Memon Fahad, El-Abbadi Mohga, Nakatani Teruyo, Taguchi Takashi, Lanske Beate, Razzaque M Shawkat

Abstract excerpt

Recent studies describe a novel role of fibroblast growth factor-23 (Fgf23)-klotho activity in the systemic regulation of calcium and phosphate homeostasis. Both Fgf23 and klotho ablated mice develop extensive vascular and soft tissue calcification. Inability to clear the required amount of phosphate by the kidney, due to the absence of Fgf23-klotho activity, leads to increased accumulation of serum phosphate in...

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Identifiers

PMID: 18528324
DOI: 10.1038/ki.2008.218
PMCID: PMC2771539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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