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Article

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.

American journal of physiology. Endocrinology and metabolism - 1 Mar 2011

Li Hua, Martin Aline, David Valentin, Quarles L Darryl

Abstract excerpt

Uncertainty exists regarding the physiologically relevant fibroblast growth factor (FGF) receptor (FGFR) for FGF23 in the kidney and the precise tubular segments that are targeted by FGF23. Current data suggest that FGF23 targets the FGFR1c-Klotho complex to coordinately regulate phosphate transport and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] production in the proximal tubule. In studies using the Hyp mouse model,...

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Source

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Identifiers

PMID: 21139072
DOI: 10.1152/ajpendo.00499.2010
PMCID: PMC3064005

Genes

FGF23
FGFR1
FGFR3
FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.PMID 21139072Read ↗

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.Semantic proximity Read ↗

Klotho Lacks an FGF23-Independent Role in Mineral Homeostasis.Semantic proximity Read ↗

Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation.Semantic proximity Read ↗

Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.Semantic proximity Read ↗

Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism.Semantic proximity Read ↗

In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

Generation of Fgfr3 conditional knockout mice.Semantic proximity Read ↗

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.Semantic proximity Read ↗

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.Semantic proximity Read ↗

Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.Semantic proximity Read ↗

A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In VivoSemantic proximity Read ↗

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