Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and Treatment

18 Mar 2025

Abstract excerpt

OBJECTIVES: Mixed phenotype acute leukemia (MPAL) often poses challenges in diagnosis and clinical management. This is the first study to assess the lineage/immunophenotype-genotype association and the significance of AML-myelodysplasia-related changes (MR, cytogenetic abnormalities and gene mutations, AML-MR-CG-Gene) in MPAL classification. METHODS: We conducted a clinicopathologic and genomic evaluation of 25...

Topics

Join the communities discussing this publication.

Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
Carcinogens and Genotoxicity Assessment

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40098409
DOI: 10.1111/ejh.14414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and TreatmentPMID 40098409Read ↗

Mixed-Phenotype Acute Leukemia: Clinical Diagnosis and Therapeutic StrategiesSemantic proximity Read ↗

Mixed-phenotype acute leukemia: current challenges in diagnosis and therapy.Semantic proximity Read ↗

An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL).Semantic proximity Read ↗

Genomic Landscape of Mixed-Phenotype Acute Leukemia.Semantic proximity Read ↗

Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes.Semantic proximity Read ↗

Acute myeloid leukemia with mixed phenotype is characterized by <i>RUNX1</i> mutations, stemness features and limited lineage plasticitySemantic proximity Read ↗

The genomic and biological complexity of mixed phenotype acute leukemia.Semantic proximity Read ↗

Optimal therapeutic strategies for mixed phenotype acute leukemia.Semantic proximity Read ↗

Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia.Semantic proximity Read ↗

Mixed Phenotype/Lineage Leukemia: Has Anything Changed for 2021 on Diagnosis, Classification, and Treatment?Semantic proximity Read ↗

Allogeneic Hematopoietic Stem Cell Transplantation with Myeloablative Conditioning Is Associated with Favorable Outcomes in Mixed Phenotype Acute Leukemia.Semantic proximity Read ↗

Defining 2 biologically and clinically distinct groups in acute leukemia with a mixed phenotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.