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Article

A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo.

Journal of the American Chemical Society - 19 Sept 2018

Moore Christopher L, Papa Louis J, Shoulders Matthew D

Abstract excerpt

Laboratory time scale evolution in vivo relies on the generation of large, mutationally diverse gene libraries to rapidly explore biomolecule sequence landscapes. Traditional global mutagenesis methods are problematic because they introduce many off-target mutations that are often lethal and can engender false positives. We report the development and application of the MutaT7 chimera, a potent and highly targeted...

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Identifiers

PMID: 29991261
DOI: 10.1021/jacs.8b04001
PMCID: PMC6166643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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