Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The classical srb4-138 mutant allele causes dissociation of yeast Mediator.

Biochemical and biophysical research communications - 27 Oct 2006

Linder Tomas, Zhu Xuefeng, Baraznenok Vera, Gustafsson Claes M

Abstract excerpt

The Mediator complex is an essential co-activator for RNA polymerase II-dependent transcription in the budding yeast Saccharomyces cerevisiae. The S. cerevisiae core Mediator complex consists of three larger domains that are termed head, middle, and tail. The Med17 subunit is located within the head domain and is essential for cell viability. A temperature-sensitive allele of the MED17 gene known as srb4-138...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mediator Complex
Share to Protein Binding
Share to RNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Temperature

Share to Trans-Activators

Share to Transcription Factors

Source

Identifiers

PMID: 16962561
DOI: 10.1016/j.bbrc.2006.08.099

Genes

MED17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The classical srb4-138 mutant allele causes dissociation of yeast Mediator.PMID 16962561Read ↗

Mediator requirement downstream of chromatin remodeling during transcriptional activation of CHA1 in yeast.Semantic proximity Read ↗

Mediator as a general transcription factor.Semantic proximity Read ↗

Mediator, known as a coactivator, can act in transcription initiation in an activator-independent manner in vivo.Semantic proximity Read ↗

Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.Semantic proximity Read ↗

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo.Semantic proximity Read ↗

Direct interaction of RNA polymerase II and mediator required for transcription in vivo.Semantic proximity Read ↗

Mediator, TATA-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast.Semantic proximity Read ↗

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression.Semantic proximity Read ↗

A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans.Semantic proximity Read ↗

Mediator is an intrinsic component of the basal RNA polymerase II machinery in vivo.Semantic proximity Read ↗

Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions.Semantic proximity Read ↗

The Mediator Complex: Progress over the Past DecadeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.