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Article

The senescence-associated secretory phenotype: the dark side of tumor suppression.

Annual review of pathology - 1 Jan 2010

Coppé Jean-Philippe, Desprez Pierre-Yves, Krtolica Ana, Campisi Judith

Abstract excerpt

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that...

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Identifiers

PMID: 20078217
DOI: 10.1146/annurev-pathol-121808-102144
PMCID: PMC4166495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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