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Article

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses.

Aging - 1 Jul 2016

Özcan Servet, Alessio Nicola, Acar Mustafa B, Mert Eda, Omerli Fatih, Peluso Gianfranco, Galderisi Umberto

Abstract excerpt

Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development. Identifying secreted factors that achieve such tasks is a challenging issue since the profile of secreted proteins depends on genotoxic stress and cell type....

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Identifiers

PMID: 27288264
DOI: 10.18632/aging.100971
PMCID: PMC4993333

Genes

MSC
IGFBP3
MMP2
PARK7
TIMP2

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