Article
Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort.
BMC genomics - 9 Jul 2018
Cologne John, Loo Lenora, Shvetsov Yurii B, Misumi Munechika, Lin Philip, Haiman Christopher A, Wilkens Lynne R, Le Marchand Loïc
Abstract excerpt
BACKGROUND: Common variants have explained less than the amount of heritability expected for complex diseases, which has led to interest in less-common variants and more powerful approaches to the analysis of whole-genome scans. Because of low frequency (low statistical power), less-common variants are best analyzed using SNP-set methods such as gene-set or pathway-based analyses. However, there is as yet no...
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