Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.

doi:10.1016/j.ajhg.2012.09.009

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Article

Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.

American journal of human genetics - 2 Nov 2012

Jin Guangfu, Ma Hongxia, Wu Chen, Dai Juncheng, Zhang Ruyang, Shi Yongyong, Lu Jiachun, Miao Xiaoping, Wang Meilin, Zhou Yifeng, Chen Jiaping, Li Huizhang, Pan Shandong, Chu Minjie, Lu Feng, Yu Dianke, Jiang Yue, Dong Jing, Hu Lingmin, Chen Yijiang, Xu Lin, Shu Yongqian, Pan Shiyang, Tan Wen, Zhou Baosen, Lu Daru, Wu Tangchun, Zhang Zhengdong, Chen Feng, Wang Xinru, Hu Zhibin, Lin Dongxin, Shen Hongbing

Abstract excerpt

Cancer susceptibility loci identified in reported genome-wide association studies (GWAS) are often tumor-specific; however, evidence of pleiotropy of some genes/loci has also been observed and biologically plausible. We hypothesized that there are important regions in the genome harboring genetic variants associated with risk of multiple types of cancer. In the current study, we attempted to map genetic variants...

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PMID: 23103227
DOI: 10.1016/j.ajhg.2012.09.009
PMCID: PMC3487121

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