Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants.

doi:10.1093/jnci/djaa058

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Article

Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants.

Journal of the National Cancer Institute - 4 Jan 2021

Campbell Peter T, Lin Yi, Bien Stephanie A, Figueiredo Jane C, Harrison Tabitha A, Guinter Mark A, Berndt Sonja I, Brenner Hermann, Chan Andrew T, Chang-Claude Jenny, Gallinger Steven J, Gapstur Susan M, Giles Graham G, Giovannucci Edward, Gruber Stephen B, Gunter Marc, Hoffmeister Michael, Jacobs Eric J, Jenkins Mark A, Le Marchand Loic, Li Li, McLaughlin John R, Murphy Neil, Milne Roger L, Newcomb Polly A, Newton Christina, Ogino Shuji, Potter John D, Rennert Gad, Rennert Hedy S, Robinson Jennifer, Sakoda Lori C, Slattery Martha L, Song Yiqing, White Emily, Woods Michael O, Casey Graham, Hsu Li, Peters Ulrike

Abstract excerpt

BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk. METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg/m2) and approximately 2.7 million single nucleotide polymorphisms with colorectal cancer risk among 14 059 colorectal cancer case (53.2% women) and 14 416 control (53.8% women) participants. All...

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PMID: 32324875
DOI: 10.1093/jnci/djaa058
PMCID: PMC7781451

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SMAD7

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