Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.

doi:10.1002/ijc.28733

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Article

Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians.

International journal of cancer - 15 Aug 2014

Zhang Ben, Jia Wei-Hua, Matsuo Keitaro, Shin Aesun, Xiang Yong-Bing, Matsuda Koichi, Jee Sun Ha, Kim Dong-Hyun, Cheah Peh Yean, Ren Zefang, Cai Qiuyin, Long Jirong, Shi Jiajun, Wen Wanqing, Yang Gong, Ji Bu-Tian, Pan Zhi-Zhong, Matsuda Fumihiko, Gao Yu-Tang, Oh Jae Hwan, Ahn Yoon-Ok, Kubo Michiaki, Thean Lai Fun, Park Eun Jung, Li Hong-Lan, Park Ji Won, Jo Jaeseong, Jeong Jin-Young, Hosono Satoyo, Nakamura Yusuke, Shu Xiao-Ou, Zeng Yi-Xin, Zheng Wei

Abstract excerpt

Genome-wide association studies (GWAS) of colorectal cancer (CRC) have been conducted primarily in European descendants. In a GWAS conducted in East Asians, we first analyzed approximately 1.7 million single-nucleotide polymorphisms (SNPs) in four studies with 1,773 CRC cases and 2,642 controls. We then selected 66 promising SNPs for replication and genotyped them in three independent studies with 3,612 cases and...

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PMID: 24448986
DOI: 10.1002/ijc.28733
PMCID: PMC4051826

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SMAD7

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