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Article

Genetic variants in TGF-β pathway are associated with ovarian cancer risk.

PloS one - 1 Jan 2011

Yin Jikai, Lu Karen, Lin Jie, Wu Lei, Hildebrandt Michelle A T, Chang David W, Meyer Larissa, Wu Xifeng, Liang Dong

Abstract excerpt

The transforming growth factor-β (TGF-β) signaling pathway is involved in a diverse array of cellular processes responsible for tumorigenesis. In this case-control study, we applied a pathway-based approach to evaluate single-nucleotide polymorphisms (SNPs) in the TGF-β signaling pathway as predictors of ovarian cancer risk. We systematically genotyped 218 SNPs from 21 genes in the TGF-β signaling pathway in 417...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21984931
DOI: 10.1371/journal.pone.0025559
PMCID: PMC3184159

Genes

SMAD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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