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Article

Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.

The Journal of biological chemistry - 5 Sept 2003

Stieber Juliane, Thomer Anna, Much Barbara, Schneider Angela, Biel Martin, Hofmann Franz

Abstract excerpt

The pacemaker channels HCN2 and HCN4 have been identified in cardiac sino-atrial node cells. These channels differ considerably in several kinetic properties including the activation time constant (tau act), which is fast for HCN2 (144 ms at -140 mV) and slow for HCN4 (461 ms at -140 mV). Here, by analyzing HCN2/4 chimeras and mutants we identified single amino acid residues in transmembrane segments 1 and 2 and...

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Source

Identifiers

PMID: 12813043
DOI: 10.1074/jbc.M305318200

Genes

HCN4
HCN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.PMID 12813043Read ↗

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