Article
A highly significant association between Cathepsin S gene polymorphisms rs12068264 and chronic obstructive pulmonary disease susceptibility in Han Chinese population.
Bioscience reports - 31 Aug 2018
Gao Sheng-Lan, Wang Ya-Hong, Li Chun-Yan, Yang La-Wei, Zou Bao-An, Chen Zu-Guang, Yao Wei-Min, Song Ze-Qing, Cheng Jun-Fen, Lin Zi-Ying, Liu Gang
Abstract excerpt
Cathepsin S (CTSS) and Sirtuin-1 (SIRT1) played crucial roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the associations between the polymorphisms of CTSS as well as SIRT1 and COPD in Asian population remain elusive. In the present study, one single nucleotide polymorphism (SNP) in rs12068264 was discovered (in 385 individuals) to be associated with the susceptibility of COPD...
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