Article
A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese.
Human molecular genetics - 1 Dec 2014
Chu Minjie, Ji Xiaoming, Chen Weihong, Zhang Ruyang, Sun Chongqi, Wang Ting, Luo Chen, Gong Jianhang, Zhu Meng, Fan Jingjing, Hou Zhiguo, Dai Juncheng, Jin Guangfu, Wu Tangchun, Chen Feng, Hu Zhibin, Ni Chunhui, Shen Hongbing
Abstract excerpt
Pneumoconiosis is the most serious occupational disease in China and its leading cause is occupational silica exposure. Pneumoconiosis takes several years to develop depending on the exposure level of silica. However, individual variation in the susceptibility to pneumoconiosis has been observed among the subjects with similar exposure. We conducted a genome-wide screening with 710,999 single nucleotide...
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