Article
Gene-environment interaction between the MMP9 C-1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease.
Environmental and molecular mutagenesis - 1 Jul 2016
Stankovic Marija, Kojic Snezana, Djordjevic Valentina, Tomovic Andrija, Nagorni-Obradovic Ljudmila, Petrovic-Stanojevic Natasa, Mitic-Milikic Marija, Radojkovic Dragica
Abstract excerpt
The aetiology of chronic obstructive pulmonary disease (COPD) is complex. While cigarette smoking is a well-established cause of COPD, a myriad of assessed genetic factors has given conflicting data. Since gene-environment interactions are thought to be implicated in aetiopathogenesis of COPD, we aimed to examine the matrix metalloproteinase (MMP) 9 C-1562T (rs3918242) functional variant and cigarette smoke in...
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