Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.

doi:10.1093/hmg/ddad095

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Article

Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.

Human molecular genetics - 5 Sept 2023

Luyapan Jennifer, Bossé Yohan, Li Zhonglin, Xiao Xiangjun, Rosenberger Albert, Hung Rayjean J, Lam Stephen, Zienolddiny Shanbeh, Liu Geoffrey, Kiemeney Lambertus A, Chen Chu, McKay James, Johansson Mattias, Johansson Mikael, Tardon Adonina, Fernandez-Tardon Guillermo, Brennan Paul, Field John K, Davies Michael P, Woll Penella J, Cox Angela, Taylor Fiona, Arnold Susanne M, Lazarus Philip, Grankvist Kjell, Landi Maria T, Christiani David C, MacKenzie Todd A, Amos Christopher I

Abstract excerpt

Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single nucleotide polymorphisms (SNPs) of 40 surfactant-related genes and lung cancer risk using genotyped data from two independent lung cancer genome-wide association studies. Discovery data included 18,082 cases and 13,780 controls of European ancestry. Replication...

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Identifiers

PMID: 37471639
DOI: 10.1093/hmg/ddad095
PMCID: PMC10481107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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