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Article

Unveiling the Role of Cathepsins on Lung Function in Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis.

International journal of chronic obstructive pulmonary disease - 1 Jan 2025

Zhang Xuemin, Li Xintong, Song Shuang, Miao Changhong, Yan Long, Xu Xiaolong, Liu Qingquan

Abstract excerpt

Background: Cathepsins are a group of proteases that can degrade the extracellular matrix of the lungs, leading to lung tissue destruction and remodeling in chronic obstructive pulmonary disease (COPD). However, the causal relationship between cathepsins and COPD remains unclear. Methods: We performed a two-sample Mendelian randomization (MR) analysis using genetic instruments for nine cathepsins (B, E, F, G, H,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40502432
DOI: 10.2147/COPD.S507283
PMCID: PMC12153959

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