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Article

Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis.

Journal of the American Chemical Society - 1 Aug 2018

Nakashima Yu, Mitsuhashi Takaaki, Matsuda Yudai, Senda Miki, Sato Hajime, Yamazaki Mami, Uchiyama Masanobu, Senda Toshiya, Abe Ikuro

Abstract excerpt

AndA, an Fe(II)/α-ketoglutarate (αKG)-dependent enzyme, is the key enzyme that constructs the unique and congested bridged-ring system of anditomin (1), by catalyzing consecutive dehydrogenation and isomerization reactions. Although we previously characterized AndA to some extent, the means by which the enzyme facilitates this drastic structural reconstruction have remained elusive. In this study, we have solved...

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PMID: 29972643
DOI: 10.1021/jacs.8b06084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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