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Article

Rational design of a zinc-dependence secondary alcohol dehydrogenase to boost its oxidation activity for α-hydroxyketones biosynthesis.

International journal of biological macromolecules - 1 Dec 2024

Pei Wenwen, Zhang Xuewen, Zeng Yan, Li Jiao, Li Ziyi, Yang Jiangang, Du Xinjun, Zhu Yueming, Sun Yuanxia

Abstract excerpt

α-Hydroxyketones, which have significant industrial applications, can be sustainably synthesized through the oxidation of secondary alcohols using secondary alcohol dehydrogenase (SADH). However, the activity of the SADH oxidation reaction is generally low, making it unsuitable for large-scale production. In this study, a rational design approach was employed to computationally engineer SADH derived from Ogataea...

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Identifiers

PMID: 39488308
DOI: 10.1016/j.ijbiomac.2024.137183

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