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Article

The substrate-bound crystal structure of a Baeyer-Villiger monooxygenase exhibits a Criegee-like conformation.

Journal of the American Chemical Society - 9 May 2012

Yachnin Brahm J, Sprules Tara, McEvoy Michelle B, Lau Peter C K, Berghuis Albert M

Abstract excerpt

The Baeyer-Villiger monooxygenases (BVMOs) are a family of bacterial flavoproteins that catalyze the synthetically useful Baeyer-Villiger oxidation reaction. This involves the conversion of ketones into esters or cyclic ketones into lactones by introducing an oxygen atom adjacent to the carbonyl group. The BVMOs offer exquisite regio- and enantiospecificity while acting on a wide range of substrates. They use...

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PMID: 22506764
DOI: 10.1021/ja211876p
PMCID: PMC3349289

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