Article
Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013
Nomura Junpei, Hashimoto Hiroshi, Ohta Takehiro, Hashimoto Yoshiteru, Wada Koichi, Naruta Yoshinori, Oinuma Ken-Ichi, Kobayashi Michihiko
Abstract excerpt
Aldoxime dehydratase (OxdA), which is a unique heme protein, catalyzes the dehydration of an aldoxime to a nitrile even in the presence of water in the reaction mixture. Unlike the utilization of H(2)O(2) or O(2) as a mediator of catalysis by other heme-containing enzymes (e.g., P450), OxdA is notable for the direct binding of a substrate to the heme iron. Here, we determined the crystal structure of OxdA. We...
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