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Article

Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase.

Acta crystallographica. Section D, Structural biology - 1 Jul 2017

Li Kunhua, Fielding Elisha N, Condurso Heather L, Bruner Steven D

Abstract excerpt

The enzyme DpgC is included in the small family of cofactor-independent dioxygenases. The chemistry of DpgC is uncommon as the protein binds and utilizes dioxygen without the aid of a metal or organic cofactor. Previous structural and biochemical studies identified the substrate-binding mode and the components of the active site that are important in the catalytic mechanism. In addition, the results delineated a...

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PMID: 28695857
DOI: 10.1107/S2059798317007045

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