Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Colony and Single Cell Level Analysis of the Heterogeneous Response of Cryptococcus neoformans to Fluconazole

19 Jun 2018

Abstract excerpt

Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug administered to treat cryptococcosis. When exposed to the inhibitory concentration of FLC, C. neoformans exhibits heteroresistance where a small subpopulation of cells develops into FLC-resistant colonies. FLC-resistant cells are aneuploids with regard to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Infections and Studies
Share to Nail Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29971221
DOI: 10.3389/fcimb.2018.00203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Colony and Single Cell Level Analysis of the Heterogeneous Response of Cryptococcus neoformans to FluconazolePMID 29971221Read ↗

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitisSemantic proximity Read ↗

Population heterogeneity in Cryptococcus neoformans: Impact on pathogenesisSemantic proximity Read ↗

Physiological Differences in Cryptococcus neoformans Strains In Vitro versus In Vivo and Their Effects on Antifungal SusceptibilitySemantic proximity Read ↗

Heteroresistance to Fluconazole Is a Continuously Distributed Phenotype among Candida glabrata Clinical Strains Associated with In Vivo Persistence.Semantic proximity Read ↗

The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistanceSemantic proximity Read ↗

Coregulation of extracellular vesicle production and fluconazole susceptibility in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata.Semantic proximity Read ↗

Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformansSemantic proximity Read ↗

Insight into the Mechanisms and Clinical Relevance of Antifungal HeteroresistanceSemantic proximity Read ↗

Insight into the Mechanisms and Clinical Relevance of Antifungal HeteroresistanceSemantic proximity Read ↗

Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformansSemantic proximity Read ↗

Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.