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Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformans

20 Jun 2024

Abstract excerpt

Cryptococcus neoformans is at the top of the list of “most wanted” human pathogens. Only three classes of antifungal drugs are available for the treatment of cryptococcosis. Studies on antifungal resistance mechanisms are limited to the investigation of how a particular antifungal drug induces resistance to a particular drug, and the impact of stresses other than antifungals on the development of antifungal...

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PMID: 38966251
DOI: 10.3389/fcimb.2024.1397724

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