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Article

Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans

13 Jun 2023

Abstract excerpt

ABSTRACT Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance. Here, we identified novel Cryptococcus neoformans regulators of extracellular vesicle (EV) biogenesis that impact FLC resistance. In particular, the...

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PMID: 37310732
DOI: 10.1128/mbio.00870-23

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