Article

Coregulation of extracellular vesicle production and fluconazole susceptibility in <i>Cryptococcus neoformans</i>

2023-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resistance. Here, we identified novel Cryptococcus neoformans regulators of extracellular vesicle (EV) biogenesis that impact FLC resistance. In particular, the t...

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Literature Corpus work: e94473db-f8b8-5e37-a79f-dc204da93404
DOI: 10.1101/2023.01.30.526212

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