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Article

IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells.

Free radical biology & medicine - 20 Aug 2018

Yang Faji, Wang Shuai, Liu Yang, Zhou Yuan, Shang Longcheng, Feng Min, Yuan Xianwen, Zhu Wei, Shi Xiaolei

Abstract excerpt

Fatty liver is one of the widely accepted marginal donor for liver transplantation, but is also more sensitive to ischemia and reperfusion injury (IRI) and produces more reactive oxygen species (ROS). Moreover, so far, no effective method has been developed to alleviate it. Endoplasmic reticulum stress (ER-stress) of hepatocyte is associated with the occurrence of fatty liver disease, but ER-stress of kupffer...

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Identifiers

PMID: 29969718
DOI: 10.1016/j.freeradbiomed.2018.06.043

Genes

STAT1
STAT6

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