Article
Interferon regulatory factor-1 activates autophagy to aggravate hepatic ischemia-reperfusion injury via the P38/P62 pathway in mice.
Scientific reports - 7 Mar 2017
Yu Yao, Li Shipeng, Wang Zhen, He Jindan, Ding Yijie, Zhang Haiming, Yu Wenli, Shi Yiwei, Cui Zilin, Wang Ximo, Wang Zhiliang, Sun Liying, Zhang Rongxin, Du Hongyin, Zhu Zhijun
Abstract excerpt
Increasing evidence has linked autophagy to a detrimental role in hepatic ischemia- reperfusion (IR) injury (IRI). Here we focus on the role of interferon regulatory factor-1 (IRF-1) in regulating autophagy to aggravate hepatic IRI. We found that IRF-1 was up-regulated during hepatic IRI and was associated with an activation of the autophagic signaling. This increased IRF-1 expression, which was allied with high...
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