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Article

Reduction in endoplasmic reticulum stress activates beige adipocytes differentiation and alleviates high fat diet-induced metabolic phenotypes.

Biochimica et biophysica acta. Molecular basis of disease - 1 May 2021

Lee Ji-Min, Park Soyoung, Lee Duckgue, Ginting Rehna Paula, Lee Man Ryul, Lee Min-Woo, Han Jaeseok

Abstract excerpt

Endoplasmic reticulum (ER) stress is closely associated with various metabolic diseases, such as obesity and diabetes. Development of beige/brite adipocytes increases thermogenesis and helps to reduce obesity. Although the relationship between ER stress and white adipocytes has been studied considerably, the possible role of ER stress and the unfolded protein response (UPR) induction in beige adipocytes...

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Identifiers

PMID: 33556486
DOI: 10.1016/j.bbadis.2021.166099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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