Article

Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in Monocytic Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways

2023-07-20

Abstract excerpt

Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin and free fatty acids. It is debated whether the endoplasmic reticulum (ER) stress in monocytic cells can contribute to amplify metabolic inflammation; if so, by which mechanism(s). To test this, metabolic stress was induced in THP-1 monocytic cells by treatm...

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Literature Corpus work: caf1a4e8-ed59-531f-97d6-f09735c63d87
DOI: 10.20944/preprints202307.1342.v1

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