Article

Astaxanthin mitigates ethanol-induced mitochondrial dysfunction and activation of mitochondrial unfolded protein response in Kupffer cells

2025-06-18

Abstract excerpt

<title>Abstract</title> <p> This study investigates the protective effects of astaxanthin (ASTX), a xanthophyll carotenoid, on ethanol-induced mitochondrial dysfunction in Kupffer cells (KCs), resident macrophages in the liver that play a key role in the pathogenesis of alcohol-related liver disease (ALD). Using immortalized mouse KCs (ImKCs) and primary mouse KCs (PmKCs) as in vitro models, we examined the role...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4c2d93c-3994-576d-a341-16086ec40614
DOI: 10.21203/rs.3.rs-6779003/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Astaxanthin mitigates ethanol-induced mitochondrial dysfunction and activation of mitochondrial unfolded protein response in Kupffer cellsDOI 10.21203/rs.3.rs-6779003/v1Read

Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseasesSemantic proximity Read

Aging promotes inflammation and steatosis in alcohol-associated liver disease in miceSemantic proximity Read

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases.Semantic proximity Read

Gene III Ergothioneine ameliorates alcoholic fatty liver disease: A dual strategy of accelerated ethanol elimination and reducing oxidative stressSemantic proximity Read

Programmed cell death in alcohol-associated liver diseaseSemantic proximity Read

Elimination of FKBP51 attenuates CCl4-induced liver injury via enhancement of mitochondrial function by increased Parkin activitySemantic proximity Read

Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Deficiency Exacerbates Alcohol-Induced Hepatic Oxidative Stress, Inflammation, Steatosis, and FibrosisSemantic proximity Read

Investigating the role of ferroptosis in the pathogenesis of murine models of metabolic dysfunction-associated steatohepatitis (MASH)Semantic proximity Read

The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver DiseaseSemantic proximity Read

PERoxiredoxin II as a Metabolic Gatekeeper Against Aflatoxin B1-Induced Hepatic Steatosis: Restoration of PPARα/γ Balance via Mitochondrial ROS ScavengingSemantic proximity Read

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.Semantic proximity Read

The effect of oleoylethanolamide supplementation on pyroptotic cell death in obese patients with non-alcoholic fatty liver disease: A double-blinded randomized controlled clinical trialSemantic proximity Read